Hydrocodone/ibuprofen

| MedlinePlus = a601006 | DailyMedID = Hydrocodone and ibuprofen | pregnancy_AU = | pregnancy_category = | ATC_prefix = N02 | ATC_suffix = AJ23

| dependency_liability = Moderate | routes_of_administration = By mouth | legal_AU = | legal_CA = | legal_UK = | legal_US = Schedule II | legal_US_comment = | legal_status = Rx-only

| CAS_number = | UNII = | KEGG_Ref = | KEGG = D02152

| bioavailability = >80% | metabolism = for hydrocodone: liver, CYP3A4; for ibuprofen: liver, CYP2C9 | elimination_half-life = for hydrocodone: 228-294 mins (3.8-4.9 hrs); for ibuprofen: 108-120 mins (1.8-2 hrs) | excretion = for hydrocodone: urinary; for ibuprofen: urine primarily (<1% unchanged) }}

Hydrocodone/ibuprofen (INNs), sold under the brand name Vicoprofen, is a fixed-dose combination analgesic medication used in short-term therapy to relieve severe pain. Vicoprofen combines the analgesic and antitussive properties of hydrocodone with the analgesic, anti-inflammatory, and antipyretic properties of ibuprofen. In contrast to hydrocodone/acetaminophen combination analgesics such as Vicodin, this hydrocodone/ibuprofen avoids some of the liver toxicity which may occur from acetaminophen, but still presents significant dangers in hydrocodone overdose, namely respiratory depression. Vicoprofen is supplied in a fixed dose combination tablet which contains hydrocodone bitartrate, USP 7.5 mg with ibuprofen, USP 200 mg. Additional strengths of generic Vicoprofen are now available, in combinations of 5 mg/200 mg and 10 mg/200 mg respectively. Provided by Wikipedia